Letizia C, De Biase L, Caliumi C, Verrelli C, Semeraro R, Subioli S, Cerci S, D'Erasmo E
Dipartimento de Scienze Cliniche, Policlinico Umberto I, 00185, Roma.
Minerva Cardioangiol. 2001 Feb;49(1):15-22.
The aim of the study was to investigate the behaviour of plasma levels of endothelin-1 (ET-1), an endothelial peptide with vasoconstrictive and proliferative actions, in patients with cardiac transplantation and in chronic treatment with cyclosporine A, some of whom became hypertensive after cardiac transplantation.
We studied: 1) 18 consecutive patients (15 M, 3F; mean age 53 +/- 7 yrs) who underwent cardiac transplantation about six months ago at least (range 6-108 months); 2) 15 patients with essential arterial hypertension (10 M, 5 F; mean age 42 +/- 15 yrs) without organ damage; 3) 21 normal subjects (15 M, 6 F; mean age 31 +/- 12 yrs). Plasma levels of ET-1 (RIA), haemodynamic and functional renal parameters were determined in all groups and plasma levels of cyclosporine were measured in patients with cardiac transplantation.
ET-1 was higher in patients with cardiac transplantation than in the other two groups (p < 0.05); instead there was no difference between patients with essential arterial hypertension and controls (p>0.05). A statistical difference was found between circulating ET-1 in hypertensive transplanted patients. In heart transplanted patients a positive and significative correlation was found between plasma levels of ET-1 and systolic (r=0.525; p<0.037) blood pressure.
本研究旨在调查内皮素 -1（ET -1）的血浆水平变化情况。ET -1是一种具有血管收缩和增殖作用的内皮肽，研究对象为心脏移植患者以及接受环孢素A长期治疗的患者，其中部分患者在心脏移植后出现高血压。
我们研究了：1）18例连续患者（15例男性，3例女性；平均年龄53±7岁），他们至少在六个月前（6 - 108个月）接受了心脏移植；2）15例原发性高血压患者（10例男性，5例女性；平均年龄42±15岁），无器官损害；3）21名正常受试者（15例男性，6例女性；平均年龄31±12岁）。测定了所有组别的ET -1血浆水平（放射免疫分析法）、血流动力学和肾脏功能参数，并测量了心脏移植患者的环孢素血浆水平。
心脏移植患者的ET -1水平高于其他两组（p < 0.05）；相反，原发性高血压患者与对照组之间无差异（p>0.05）。在高血压移植患者的循环ET -1之间发现了统计学差异。在心脏移植患者中，ET -1血浆水平与收缩压（r = 0.525；p < 0.037）之间存在正相关且具有统计学意义。
