Mattson D L
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226-0509, USA.
Am J Hypertens. 2001 May;14(5 Pt 1):405-8. doi: 10.1016/s0895-7061(00)01285-1.
The present study was performed to compare the resting level of arterial blood pressure when monitored for 24 h/day in outbred Swiss Webster (SW) and inbred C57BL/ 6J, A/J, C3HeB/FeJ, and SWR/J mice. Mean arterial pressure (MAP) and heart rate (HR) varied throughout the day, with maximal values observed in the hours of darkness. Systolic (SAP), MAP, and diastolic (DAP) arterial blood pressure averaged 122 +/- 2, 112 +/- 2, and 102 +/- 2 mm Hg, respectively, in conscious SW mice (N = 6). No differences were detected in the 24-h averages of MAP between SW, C57BL/6J (N = 7), A/J (N = 5), C3HeB/FeJ (N = 5), or SWR/J (N = 7) mice maintained on a normal sodium diet. Average daily heart rate (HR) was highest in the C3HeB/FeJ (665 +/- 15 beats/min) and lowest in the C57BL/6J (594 +/- 9 beats/min). The MAP was significantly increased in SW mice administered L-NAME (133 +/- 2 mm Hg, N = 5) and significantly decreased in SW mice administered captopril (99 +/- 2 mm Hg, N = 5). These studies demonstrate similar levels of resting arterial pressure in different mouse strains under baseline conditions.
本研究旨在比较远交系瑞士韦伯斯特（SW）小鼠和近交系C57BL/6J、A/J、C3HeB/FeJ及SWR/J小鼠在每天24小时监测下的动脉血压静息水平。平均动脉压（MAP）和心率（HR）在一天中有所变化，在黑暗时段观察到最大值。清醒SW小鼠（N = 6）的收缩压（SAP）、MAP和舒张压（DAP）平均分别为122±2、112±2和102±2 mmHg。维持正常钠饮食的SW、C57BL/6J（N = 7）、A/J（N = 5）、C3HeB/FeJ（N = 5）或SWR/J（N = 7）小鼠在24小时MAP平均值上未检测到差异。平均每日心率（HR）在C3HeB/FeJ小鼠中最高（665±15次/分钟），在C57BL/6J小鼠中最低（594±9次/分钟）。给予L - NAME的SW小鼠MAP显著升高（133±2 mmHg，N = 5），给予卡托普利的SW小鼠MAP显著降低（99±2 mmHg，N = 5）。这些研究表明在基线条件下不同小鼠品系的静息动脉压水平相似。
