Sherry E, Boeck H, Warnke P H
OR Design Unit, University of Sydney, Nepean Hospital, PO Box 63, Penrith, NSW 2750, Australia.
BMC Surg. 2001;1:1. doi: 10.1186/1471-2482-1-1. Epub 2001 May 16.
Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE, are an increasing problem world-wide, causing intractable wound infections. Complex phytochemical extracts such as tea tree oil and eucalypt-derived formulations have been shown to have strong bactericidal activity against MRSA in vitro. Polytoxinol (PT) antimicrobial, is the trade name of a range of antimicrobial preparations in solution, ointment and cream form.
We report the first use of this drug, administered percutaneously, via calcium sulphate pellets (Osteoset,TM), into bone, to treat an intractable MRSA infection of the lower tibia in an adult male.
Over a three month period his symptoms resolved with a healing response on x-ray and with a reduced CRP.
耐抗生素细菌，如耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE），在全球范围内是一个日益严重的问题，会导致难以治愈的伤口感染。复杂的植物化学提取物，如茶树油和桉树叶衍生制剂，已被证明在体外对MRSA具有强大的杀菌活性。聚毒素醇（PT）抗菌剂，是一系列溶液、软膏和乳膏形式的抗菌制剂的商品名。
我们报告了该药物首次经皮通过硫酸钙颗粒（Osteoset，TM）注入骨内，用于治疗一名成年男性下肢胫骨难治性MRSA感染。
在三个月的时间里，他的症状得到缓解，X线显示有愈合反应，C反应蛋白（CRP）降低。
