Halcón Linda, Milkus Kelly
School of Nursing, University of Minnesota, Minneapolis 55455, USA.
Am J Infect Control. 2004 Nov;32(7):402-8. doi: 10.1016/S0196655304003657.
Antibiotic-resistant bacteria continue to be a major health concern worldwide. In particular, Staphylococcus aureus, both methicillin-resistant and -sensitive, are of concern in their ability to cause difficult skin and underlying tissue infections. Melaleuca alternifolia oil (tea tree oil), an essential oil, has demonstrated promising efficacy in treating these infections. Tea tree oil has been used for centuries as a botanical medicine, and has only in recent decades surfaced in the scientific literature as a promising adjunctive wound treatment. Tea tree oil is antimicrobial, anti-inflammatory, and has demonstrated ability to activate monocytes. There are few apparent side effects to using tea tree oil topically in low concentrations, with contact dermatitis being the most common. Tea tree oil has been effective as an adjunctive therapy in treating osteomyelitis and infected chronic wounds in case studies and small clinical trials. There is a need for larger clinical trials to further examine efficacy of tea tree oil as an adjunctive wound therapy, as well as improved guidelines for developing plant-based medicines.
抗生素耐药性细菌仍然是全球主要的健康问题。特别是金黄色葡萄球菌，无论是耐甲氧西林还是对甲氧西林敏感的，都因其能够引发严重的皮肤和深部组织感染而受到关注。互叶白千层油（茶树油），一种精油，在治疗这些感染方面已显示出有前景的疗效。茶树油作为一种植物药已经使用了几个世纪，直到最近几十年才在科学文献中作为一种有前景的辅助伤口治疗方法出现。茶树油具有抗菌、抗炎作用，并已证明有激活单核细胞的能力。局部使用低浓度茶树油几乎没有明显副作用，接触性皮炎是最常见的。在病例研究和小型临床试验中，茶树油作为辅助治疗在治疗骨髓炎和感染的慢性伤口方面是有效的。需要进行更大规模的临床试验来进一步研究茶树油作为辅助伤口治疗的疗效，以及完善开发植物性药物的指南。
