Trappe H J, Pfitzner P
Medizinische Klinik II (Schwerpunkete Kardiologie und Angiologie) Universitätsklinik Marienhospital, Ruhr-Universität Bochum, Hölkeskampring 40, 44625 Herne.
Z Kardiol. 2001;90 Suppl 4:36-44.
Atrial premature beats are frequently diagnosed during pregnancy (PR), supraventricular tachycardia (SVT; atrial tachycardia, AV nodal reentrant tachycardia, circus movement tachycardia) less frequently. For acute therapy, electrical cardioversion with 50-100 J is indicated in all unstable patients (pts). In stable SVT the initial therapy includes the vagal maneuver to terminate breakthrough tachycardias. For short-term management, when the vagal maneuver fails, intravenous adenosine is the first-choice drug and may safely terminate the arrhythmia. For long-term therapy, beta-blocking agents with beta 1 selectivity are first-line drugs; class Ic agents or the class III drug sotalol (sot) are effective and therapeutic alternatives. Ventricular premature beats are also frequently present during PR and benign in most pts; however, malignant ventricular tachyarrhythmias (sustained ventricular tachycardia [VT], ventricular flutter [VFlut], ventricular fibrillation [VF]) were observed less frequently. Electrical cardioversion is necessary in all pts with a hemodynamically unstable situation and life-threatening ventricular tachyarrhythmias; in hemodynamically stable pts, initial therapy with ajmaline, procainamide or lidocaine is indicated. If prophylactic therapy is needed, beta-blocking agents with beta 1 selectivity are considered as first-choice drugs. If this therapy is ineffective, class Ic agents or sot can be considered. In pts with syncopal VT, VF, VFlut or aborted sudden death an implantable cardioverter-defibrillator is indicated. In pts with symptomatic bradycardia, a pacemaker can be implanted using echocardiography at any stage of PR. The treatment of the pregnant patient with cardiac arrhythmias requires important modification of the standard practice of arrhythmia management. The goal of therapy is to protect the patient and fetus through delivery, after which chronic or definitive therapy can be administered.
孕期(PR)常诊断出房性早搏,室上性心动过速(SVT;房性心动过速、房室结折返性心动过速、折返性心动过速)则较少见。对于急性治疗,所有不稳定患者(pts)均需采用50 - 100 J的电复律。对于稳定的SVT,初始治疗包括采用迷走神经手法终止突发的心动过速。对于短期治疗,当迷走神经手法无效时,静脉注射腺苷是首选药物,且可安全地终止心律失常。对于长期治疗,具有β1选择性的β受体阻滞剂是一线药物;Ic类药物或III类药物索他洛尔(sot)有效,是治疗的替代选择。室性早搏在PR期间也很常见,且在大多数患者中为良性;然而,恶性室性心律失常(持续性室性心动过速[VT]、心室扑动[VFlut]、心室颤动[VF])较少见。所有血流动力学不稳定且有危及生命的室性心律失常的患者均需进行电复律;对于血流动力学稳定的患者,初始治疗可选用阿义马林、普鲁卡因胺或利多卡因。如果需要预防性治疗,具有β1选择性的β受体阻滞剂被视为首选药物。如果该治疗无效,可考虑Ic类药物或索他洛尔。对于有晕厥性VT、VF、VFlut或心脏骤停复苏成功的患者,建议植入植入式心脏复律除颤器。对于有症状性心动过缓的患者,在PR的任何阶段均可使用超声心动图引导植入起搏器。患有心律失常的孕妇的治疗需要对心律失常管理的标准做法进行重要调整。治疗的目标是在分娩前保护患者和胎儿,分娩后可进行慢性或确定性治疗。