Muir A J, Edwards L J, Sanders L L, Bollinger R R, Koruda M J, Bachwich D R, Provenzale D
Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Am J Gastroenterol. 2001 May;96(5):1480-5. doi: 10.1111/j.1572-0241.2001.03801.x.
The ileal pouch anal anastomosis is a safe and effective procedure but is also associated with pouchitis, small bowel obstruction, and incontinence. We prospectively evaluated the health-related quality of life using generic and disease-specific measures in a cohort of patients with ulcerative colitis undergoing ileal pouch anal anastomosis.
Health-related quality of life measures included the Time Trade-off, Rating Form of IBD Patient Concerns, and the Short-Form 36. Assessments occurred preoperatively and 1, 6, and 12 months postoperatively.
Time Trade-off scores had significantly improved at the 1-month postoperative assessment and approached perfect health at the 12-month postoperative assessment. The Rating Form of IBD Patient Concerns revealed a significant reduction in patient concerns at 1 month, and this difference persisted at 6 and 12 months. Seven of the eight subscales of the Short-Form 36 revealed improved health-related quality of life postoperatively.
Health-related quality of life improved after ileal pouch anal anastomosis when assessed with both generic and disease-specific measures. Improvements were observed as early as 1 month postoperatively. These results may guide patients and physicians as they consider and prepare for the impact of ileal pouch anal anastomosis.
回肠储袋肛管吻合术是一种安全有效的手术，但也与储袋炎、小肠梗阻和大便失禁有关。我们前瞻性地使用通用和疾病特异性指标评估了一组接受回肠储袋肛管吻合术的溃疡性结肠炎患者的健康相关生活质量。
健康相关生活质量指标包括时间权衡法、炎症性肠病患者关注评定量表和简短健康调查问卷36项。评估在术前以及术后1、6和12个月进行。
时间权衡法评分在术后1个月的评估中显著改善，在术后12个月的评估中接近完美健康状态。炎症性肠病患者关注评定量表显示患者关注在1个月时显著减少，且这种差异在6个月和12个月时持续存在。简短健康调查问卷36项的八个子量表中有七个显示术后健康相关生活质量有所改善。
当使用通用和疾病特异性指标进行评估时，回肠储袋肛管吻合术后健康相关生活质量得到改善。术后1个月就观察到了改善。这些结果可能会在患者和医生考虑并为回肠储袋肛管吻合术的影响做准备时提供指导。
