Bajdik C D, Phillips N, Huchcroft S, Hill G B, Gallagher R P
Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.
Can J Urol. 2001 Apr;8(2):1229-33.
Some families seem to have an increased risk of several different cancers and a reduced risk of others. Either genetic predisposition or a shared environment may explain this familial clustering, and the type of cause can affect how family members should be advised. We used data from a case-control study to examine the risk of cancer in the mother, sisters and brothers of men with testicular cancer. Our results show a significant relative risk (RR=1.7; 95% confidence interval (CI): 1.05-2.6) of cancer for sisters of testicular cancer patients in comparison with the sisters of controls. When data were combined for brothers and sisters, the RR for all cancers was 1.53 (CI: 1.1-2.3). Despite the limitations of our data, there is evidence for cancer clustering in the families of testicular cancer patients. Unfortunately, the evidence is consistent with either a genetic or environmental etiology.
一些家族似乎患几种不同癌症的风险增加，而患其他癌症的风险降低。遗传易感性或共同的环境可能解释这种家族聚集现象，病因类型会影响对家庭成员的建议方式。我们使用一项病例对照研究的数据来检查睾丸癌男性患者的母亲、姐妹和兄弟患癌症的风险。我们的结果显示，与对照组的姐妹相比，睾丸癌患者的姐妹患癌症的相对风险显著（RR = 1.7；95%置信区间(CI)：1.05 - 2.6）。当将兄弟和姐妹的数据合并时，所有癌症的RR为1.53（CI：1.1 - 2.3）。尽管我们的数据存在局限性，但有证据表明睾丸癌患者家族中存在癌症聚集现象。不幸的是，证据与遗传或环境病因均相符。
