Hemminki Kari, Chen Bowang
Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
Int J Androl. 2006 Feb;29(1):205-10. doi: 10.1111/j.1365-2605.2005.00599.x.
We used the nationwide Swedish Family-Cancer Database to analyse the risk for testicular cancer in offspring through parental and sibling probands. Among 0 to 70-year-old offspring, 4,586 patients had testicular cancer. Standardized incidence ratios for familial risk were 3.8-fold when a father and 7.6-fold when a brother had testicular cancer. Testicular cancer was associated with leukaemia, distal colon and kidney cancer, melanoma, connective tissue tumours and lung cancer in families. Non-seminoma was associated with maternal lung cancer but the risk was highest for the late-onset cases, providing no support to the theory of the in utero effect of maternal smoking on the son's risk of testicular cancer. However, the theory cannot be excluded but should be taken up for study when further data are available on maternal smoking. The high familial risk may be the product of shared childhood environment and heritable causes.
我们使用瑞典全国性家庭癌症数据库，通过父母及同胞先证者来分析子代患睾丸癌的风险。在0至70岁的子代中，有4586例患者患有睾丸癌。当父亲患睾丸癌时，家族风险的标准化发病率比为3.8倍；当兄弟患睾丸癌时，家族风险的标准化发病率比为7.6倍。在家族中，睾丸癌与白血病、远端结肠癌、肾癌、黑色素瘤、结缔组织肿瘤和肺癌有关。非精原细胞瘤与母亲患肺癌有关，但晚发型病例的风险最高，这并不支持母亲吸烟对儿子患睾丸癌风险的子宫内影响理论。然而，该理论不能被排除，当有更多关于母亲吸烟的进一步数据时，应进行研究。高家族风险可能是共同童年环境和遗传因素的产物。
