McKenna P J, Scheinman H Z
Crit Care Med. 1975 Jan-Feb;3(1):8-12. doi: 10.1097/00003246-197501000-00003.
This report describes an unusual hemolytic transfusion reaction. A group O donor was inadvertently transfused with 100 ml of group A red cells during the course of plasmapheresis. Granulocytopenia, thrombocytopenia, hypofibrinogenemia and low levels of factors V, VIII, and IX developed immediately after the infusion. The levels of the cellular elements and coagulation proteins returned to normal in less than an hour; too rapid for a de novo synthesis after consumption of coagulation proteins. We postulate that activation of the kinin system was responsible for the phenomena rather than intravascular coagulation with secondary fibrinolysis.
本报告描述了一例罕见的溶血性输血反应。一名O型供血者在血浆置换过程中意外输注了100毫升A型红细胞。输注后立即出现粒细胞减少、血小板减少、纤维蛋白原血症降低以及V、VIII和IX因子水平降低。细胞成分和凝血蛋白水平在不到一小时内恢复正常；对于凝血蛋白消耗后的重新合成来说太快了。我们推测激肽系统的激活是导致这些现象的原因，而非继发性纤维蛋白溶解的血管内凝血。
