Huynen M A, Snel B, Bork P
EMBL, Biocomputing, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Trends Genet. 2001 Jun;17(6):304-6. doi: 10.1016/s0168-9525(01)02302-2.
Comparisons of the gene order in closely related genomes reveal a major role for inversions in the genome shuffling process. In contrast to prokaryotes, where the inversions are predominantly large, half of the inversions between Saccharomyces cerevisiae and Candida albicans appear to be small, often encompassing only a single gene. Overall the genome rearrangement rate appears higher in eukaryotes than in prokaryotes, and the current genome data do not indicate that functional constraints on the co-expression of neighboring genes have a large role in conserving eukaryotic gene order. Nevertheless, qualitatively interesting examples of conservation of gene order in eukaryotes can be observed.
对亲缘关系密切的基因组中的基因顺序进行比较，揭示了倒位在基因组重排过程中的主要作用。与原核生物不同，原核生物中的倒位主要是大片段的，而酿酒酵母和白色念珠菌之间的倒位有一半似乎是小片段的，通常只包含一个基因。总体而言，真核生物中的基因组重排率似乎高于原核生物，而且目前的基因组数据并未表明对相邻基因共表达的功能限制在维持真核生物基因顺序方面发挥了很大作用。然而，可以观察到真核生物中基因顺序保守性的一些定性有趣的例子。
