促进炎症性莱姆关节炎的宿主-病原体相互作用：利用小鼠模型剖析疾病过程。

Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes.

作者信息

Wooten R M, Weis J J

机构信息

Division of Cell Biology and Immunology, Department of Pathology, 50 North Medical Drive, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

出版信息

Curr Opin Microbiol. 2001 Jun;4(3):274-9. doi: 10.1016/s1369-5274(00)00202-2.

DOI:10.1016/s1369-5274(00)00202-2

PMID:11378478

Abstract

Recent studies have confirmed the infectious and inflammatory nature of arthritis induced by Borrelia burgdorferi, or Lyme arthritis. This arthritis is directed by the presence of the bacteria in joint tissue, and is mediated through activation of the Toll-like receptor 2 (TLR2) signaling pathways by borrelial lipoproteins. Several host genes regulate the severity of arthritis, possibly by regulating the balance of pro- and anti-inflammatory responses.

摘要

最近的研究证实了由伯氏疏螺旋体引起的关节炎（即莱姆关节炎）具有感染性和炎症性。这种关节炎是由关节组织中细菌的存在所引发的，并通过伯氏疏螺旋体脂蛋白激活Toll样受体2（TLR2）信号通路来介导。一些宿主基因可能通过调节促炎和抗炎反应的平衡来调控关节炎的严重程度。