Middeldorp S, Libourel E J, Hamulyák K, Van der Meer J, Büller H R
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Br J Haematol. 2001 May;113(2):553-5. doi: 10.1046/j.1365-2141.2001.02766.x.
The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post-partum period. The absolute risk for pregnancy-related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy-related VTE in women with a symptomatic first-degree relative was 17% per pregnancy (95%CI 4.7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy.
孕期及产后静脉血栓栓塞（VTE）风险增加。携带因子V莱顿突变的杂合子女性发生与妊娠相关VTE的绝对风险约为2%，但关于纯合子女性这一风险的研究结果相互矛盾。在一项回顾性家族研究中，我们发现有症状的一级亲属的女性每妊娠一次发生与妊娠相关VTE的风险为17%（95%可信区间4.7-37.4）。产后期间，对于来自有症状家族的无症状纯合子女性似乎应进行抗凝预防，而在孕期则可根据个体情况决定是否进行预防。
