前列腺素经犬中枢神经系统介导产生的心血管效应。

Cardiovascular effects of prostaglandins mediated by the central nervous system of the dog.

Lavery H A, Lowe R D, Scroop G C

Br J Pharmacol. 1970 Jul;39(3):511-9. doi: 10.1111/j.1476-5381.1970.tb10359.x.

Abstract

Prostaglandins A(1), E(1), F(1alpha) and F(2alpha) were infused into the vertebral artery of the chloralose-anaesthetized greyhound and the resulting cardiovascular responses were compared with those obtained on intravenous and intracarotid infusions in the same dose range.2. Infusions of PGF(2alpha) intravertebrally (4-64 (ng/kg)/min) caused an increase of blood pressure, tachycardia and a fall of central venous pressure. Cardiac output was increased and peripheral resistance was essentially unchanged. There was never any response to intravenous or intracarotid PGF(2alpha) infusions in this dose range.3. PGF(1alpha) was found to have similar effects to PGF(2alpha) but it was much less potent.4. PGE(1) infusions (4-360 (ng/kg)/min) into the vertebral artery caused a tachycardia which was greater than that obtained with intracarotid or intravenous infusions, but there was no significant effect on blood pressure.5. Infusions of PGA(1) caused a small fall of blood pressure accompanied by an increase of heart rate and the dose response relationships were similar for all three routes of administration.6. It is concluded that some prostaglandins can activate cardioregulatory centres within the territory of distribution of the vertebral artery. Prostaglandin F(2alpha) is the most potent of these.

摘要

将前列腺素A(1)、E(1)、F(1α)和F(2α)注入用氯醛糖麻醉的灵缇犬的椎动脉，并将由此产生的心血管反应与在相同剂量范围内静脉内和颈内动脉注射时获得的反应进行比较。
经椎动脉注入PGF(2α)(4 - 64(纳克/千克)/分钟)会导致血压升高、心动过速和中心静脉压下降。心输出量增加，外周阻力基本不变。在这个剂量范围内，静脉内或颈内动脉注射PGF(2α)从未有任何反应。
发现PGF(1α)与PGF(2α)有相似的作用，但效力要小得多。
经椎动脉注入PGE(1)(4 - 360(纳克/千克)/分钟)会引起心动过速，其程度大于颈内动脉或静脉内注射时的情况，但对血压没有显著影响。
注入PGA(1)会导致血压略有下降，同时心率增加，并且三种给药途径的剂量反应关系相似。
得出的结论是，一些前列腺素可以激活椎动脉分布区域内的心脏调节中枢。其中前列腺素F(2α)最为有效。