Threlfall E J, Ward L R
Central Public Health Laboratory, London, United Kingdom.
Emerg Infect Dis. 2001 May-Jun;7(3):448-50. doi: 10.3201/eid0703.010315.
In 1999, 23% of Salmonella enterica serotype Typhi isolates from patients in the United Kingdom exhibited decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/L); more than half were also resistant to chloramphenicol, ampicillin, and trimethoprim. Increasing numbers of treatment failures have been noted. Most infections have been in patients with a recent history of travel to India and Pakistan.
1999年,从英国患者中分离出的伤寒沙门氏菌Typhi血清型菌株中,23%对环丙沙星的敏感性降低(最低抑菌浓度为0.25 - 1.0毫克/升);超过半数还对氯霉素、氨苄西林和甲氧苄啶耐药。治疗失败的病例越来越多。大多数感染发生在近期有前往印度和巴基斯坦旅行史的患者中。