氯霉素仍然是治疗伤寒的首选药物吗？
Does chloramphenicol remain the drug of choice for typhoid?
作者信息
Rowe B, Threlfall E J, Ward L R
出版信息
Epidemiol Infect. 1987 Jun;98(3):379-83. doi: 10.1017/s0950268800062142.
Abstract
Of 2356 strains of Salmonella typhi isolated in Britain in the 8-year period 1978-85, 2345 (99.53%) were sensitive to all antibiotics tested and 11 (0.47%) were chloramphenicol-resistant; chloramphenicol resistance was plasmid-mediated in 6 strains. It is concluded that chloramphenicol remains a satisfactory first-line choice of drug for typhoid fever in Britain.
摘要
在1978年至1985年的8年期间，英国分离出的2356株伤寒沙门氏菌中，2345株（99.53%）对所有测试抗生素敏感，11株（0.47%）对氯霉素耐药；6株氯霉素耐药是由质粒介导的。得出的结论是，在英国，氯霉素仍然是治疗伤寒热令人满意的一线用药选择。
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