Makino T, Nakamura S, Nakayama H, Mihara M
Department of Dermatology, Faculty of Medicine, Tottori University, Yonago, Japan.
J Cutan Pathol. 1998 Nov;25(10):568-71. doi: 10.1111/j.1600-0560.1998.tb01743.x.
We report an 84-year-old man with extramammary Paget's disease (EMPD) involving the genital region. Microscopic examination revealed very few clear cells appearing pagetoid in the lower portion of prickle cell layer of the right axilla epidermis, with no clinically detectable eruption. Their histochemical, immunohistochemical and lectin-binding reactions were almost identical to those in the genital lesion. However, although the axillary lesion was diagnosed as subclinical Paget's condition, the clinical course showed no aggressive or destructive nature. Our case suggests that not all subclinical Paget's conditions become malignant, and that in some cases the clear cells may be precursors of Paget's cells developing multifocally.
我们报告一例84岁男性，患有累及生殖器区域的乳房外佩吉特病（EMPD）。显微镜检查显示，右腋窝表皮棘细胞层下部有极少数呈佩吉特样的透明细胞，临床上未检测到皮疹。它们的组织化学、免疫组织化学和凝集素结合反应与生殖器病变中的反应几乎相同。然而，尽管腋窝病变被诊断为亚临床佩吉特病，但临床病程并无侵袭性或破坏性。我们的病例表明，并非所有亚临床佩吉特病都会恶变，在某些情况下，透明细胞可能是多灶性发展的佩吉特细胞的前体。
