Jones R E, Austin C, Ackerman A B
Am J Dermatopathol. 1979 Summer;1(2):101-32. doi: 10.1097/00000372-197900120-00002.
Fifty-five patients with extramammary Paget's disease were the source of material for this study. Step-sections were done through most of the specimens. Clinical information, including follow-up, was obtained on 45 of the 55 patients. Extramammary Paget's disease could be divided histologically according to where Paget cells were found, namely: 1) wholly within the epidermis and the epithelial structures of adnexa, and the dermis; 3) within the epidermis, the epithelial structures of adnexa, and contiguous epithelia of other organs such as the genitourinary and gastrointestinal tracts. Our conclusions are that extramammary Paget's disease is more than one disease and in most instances begins in the epidermis as an adenocardinoma and extends from there into contiguous epithelium of hair follicles and eccrine sweat ducts. Uncommonly, Paget cells extend from the epidermis into the dermis and from there may metastasize. Rarely, extramammary Paget's disease results from direct extension into the skin of an adenocarcinoma in a contiguous organ such as the genitourinary or gastrointestinal tract.
55例乳房外佩吉特病患者是本研究的材料来源。对大多数标本进行了连续切片。在55例患者中的45例获得了包括随访在内的临床信息。乳房外佩吉特病可根据佩吉特细胞的发现部位进行组织学分类，即：1）完全位于表皮、附属器的上皮结构及真皮内；3）位于表皮、附属器的上皮结构及其他器官如泌尿生殖道和胃肠道的相邻上皮内。我们的结论是，乳房外佩吉特病不止一种疾病，在大多数情况下始于表皮，为腺上皮癌，并从那里延伸至毛囊和小汗腺导管的相邻上皮。罕见情况下，佩吉特细胞从表皮延伸至真皮并可能从那里发生转移。极少数情况下，乳房外佩吉特病是由相邻器官如泌尿生殖道或胃肠道的腺癌直接蔓延至皮肤所致。
