Uhr J W, Capra J D, Vitetta E S, Cook R G
Science. 1979 Oct 19;206(4416):292-7. doi: 10.1126/science.113876.
The I region of the major histocompatibility complex contains immune response genes that display considerable polymorphism; that is, there are many alleles at each locus. These genes regulate the immune response to antigen by mediating intercellular communication among lymphoreticular cells. An analysis of the primary structure of the products of two subregions of (I-A, I-E/C) was undertaken in order to understand the genetic organization of the region, the evolution of the genes and, eventually, their function.
主要组织相容性复合体的I区域包含显示出相当多多态性的免疫反应基因；也就是说，每个位点都有许多等位基因。这些基因通过介导淋巴网状细胞之间的细胞间通讯来调节对抗原的免疫反应。为了了解该区域的遗传组织、基因的进化以及最终它们的功能，对（I-A、I-E/C）两个亚区域产物的一级结构进行了分析。
