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人类B细胞同种异体抗原DC1、MT1和LB12彼此相同，但与HLA - DR抗原不同。

Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

作者信息

Shackelford D A, Mann D L, van Rood J J, Ferrara G B, Strominger J L

出版信息

Proc Natl Acad Sci U S A. 1981 Jul;78(7):4566-70. doi: 10.1073/pnas.78.7.4566.

DOI:10.1073/pnas.78.7.4566
PMID:6974868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC319833/
Abstract

Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.

摘要

一些人B淋巴母细胞系显示至少表达两种类型的Ia样抗原。一种抗原由针对HLA-DR的同种抗血清所界定，另一种抗原由针对与HLA-DR处于连锁不平衡状态的特异性DC1、MT1（MB1）和LB12的同种抗血清及单克隆抗体所界定。DC1分子的亚基与DR分子的亚基不同。这两种分子的轻链在结构上具有多态性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/9e847746bb32/pnas00658-0610-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/8051c00e639d/pnas00658-0608-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/612ef08d11e1/pnas00658-0609-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/be591963356d/pnas00658-0609-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/3576e57b82ac/pnas00658-0610-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/9e847746bb32/pnas00658-0610-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/8051c00e639d/pnas00658-0608-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/e94e1fab560d/pnas00658-0608-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/612ef08d11e1/pnas00658-0609-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/be591963356d/pnas00658-0609-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/3576e57b82ac/pnas00658-0610-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2a5/319833/9e847746bb32/pnas00658-0610-b.jpg

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本文引用的文献

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Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.根据核苷酸序列预测的一种HLA - DR抗原样β链的完整氨基酸序列：与免疫球蛋白以及HLA - A、- B和 - C抗原的相似性。
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cDNA clones for the heavy chain of HLA-DR antigens obtained after immunopurification of polysomes by monoclonal antibody.通过单克隆抗体对多核糖体进行免疫纯化后获得的 HLA - DR 抗原重链的 cDNA 克隆。
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Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).抑制性T细胞参与针对人Ia样抗原（p23,30）的异种抗血清的免疫抑制活性。
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Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.人类B细胞同种异体抗原的多态性：HLA系统内三个基因座的证据。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6101-4. doi: 10.1073/pnas.77.10.6101.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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