复杂法医DNA混合图谱的解读
Interpretation of complex forensic DNA mixtures.
作者信息
Ladd C, Lee H C, Yang N, Bieber F R
机构信息
State of Connecticut Department of Public Safety, CT Forensic Laboratory, 278 Colony Street, Meriden, CT, USA.
出版信息
Croat Med J. 2001 Jun;42(3):244-6.
Forensic evidentiary samples routinely contain DNA from multiple contributors. The interpretation of these mixtures can be a challenging task for the DNA scientist. Several approaches are discussed (no calculation- qualitative statement; probability of exclusion; likelihood ratio estimates; presumptive genotype assignment based on peak heights), which have been employed to assess the significance of an inclusion/match when DNA mixtures have been detected in casework samples. These statistical approaches are discussed in light of technical challenges that can arise when evaluating evidentiary samples.
法医证据样本通常包含来自多个贡献者的DNA。对这些混合样本进行解读对DNA科学家来说可能是一项具有挑战性的任务。本文讨论了几种方法（无计算——定性陈述；排除概率；似然比估计；基于峰高的推定基因型分配），这些方法已被用于评估在实际案件样本中检测到DNA混合样本时包含/匹配的显著性。鉴于在评估证据样本时可能出现的技术挑战，对这些统计方法进行了讨论。
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