Boldogh I R, Yang H C, Pon L A
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Traffic. 2001 Jun;2(6):368-74. doi: 10.1034/j.1600-0854.2001.002006368.x.
During the past decade significant advances were made toward understanding the mechanism of mitochondrial inheritance in the yeast Saccharomyces cerevisiae. A combination of genetics, cell-free assays and microscopy has led to the discovery of a great number of components. These fall into three major categories: cytoskeletal elements, mitochondrial membrane components and regulatory proteins. These proteins mediate activities, including movement of mitochondria from mother cells to buds, segregation of mitochondria and mitochondrial DNA, and equal distribution of the organelle between mother cells and buds during yeast cell division.
在过去十年中，人们在了解酿酒酵母中线粒体遗传机制方面取得了重大进展。遗传学、无细胞分析和显微镜技术的结合促成了大量组分的发现。这些组分主要分为三大类：细胞骨架成分、线粒体膜成分和调节蛋白。这些蛋白质介导多种活动，包括线粒体从母细胞向芽的移动、线粒体和线粒体DNA的分离，以及酵母细胞分裂过程中该细胞器在母细胞和芽之间的均匀分布。
