可乐定对猫血管运动中枢兴奋性的影响。
Effect of clonidine on the excitability of vasomotor loci in the cat.
作者信息
Dhawan B N, Johri M B, Singh G B, Srimal R C, Viswesaram D
出版信息
Br J Pharmacol. 1975 May;54(1):17-21. doi: 10.1111/j.1476-5381.1975.tb07404.x.
Abstract
- The effect of clonidine on the direct excitability of hypothalamic, medullary and spinal vasomotor loci has been investigated in cats anaesthetized with chloralose. 2. Clonidine inhibited the excitability of these loci when it was localized to the central sites by intracerebroventricular, intravertebral arterial or intrathecal injection in very low doses (1-2 mug). 3. Topical application of clonidine (0.01 percent and 1.0 percent) to the floor of the fourth ventricle inhibited pressor responses evoked either by stimulation of medullary or hypothalamic vasomotor areas. Inhibition of the pressor responses was accompanied by hypotension and bradycardia in many experiments. 4. It appears that effects of clonidine on the vasomotor loci of the medulla oblongata and the spinal cord contribute to its hypotensive action.
摘要
- 已在用氯醛糖麻醉的猫身上研究了可乐定对下丘脑、延髓和脊髓血管运动位点直接兴奋性的影响。2. 当通过脑室内、椎动脉内或鞘内注射极低剂量（1 - 2微克）将可乐定定位到中枢部位时，它会抑制这些位点的兴奋性。3. 将可乐定（0.01%和1.0%）局部应用于第四脑室底部可抑制由刺激延髓或下丘脑血管运动区域引起的升压反应。在许多实验中，升压反应的抑制伴随着低血压和心动过缓。4. 看来可乐定对延髓和脊髓血管运动位点的作用有助于其降压作用。
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