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Analysis of the central vasomotor effects of (-)-N-(1-phenylethyl)guanidine, a new adrenergic neuron blocking agent.新型肾上腺素能神经元阻断剂（-）-N-（1-苯乙基）胍的中枢血管运动效应分析
Can J Physiol Pharmacol. 1969 Aug;47(8):725-9. doi: 10.1139/y69-123.
2
[Central effect of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride].[2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐的中枢作用]
Arzneimittelforschung. 1968 Sep;18(9):1147-53.
3
Evidence for a central hypotensive mechanism of 2-(2,6-dichlorophenylamino)-2-imidazoline (Catapresan, ST-155).2-(2,6-二氯苯基氨基)-2-咪唑啉（可乐宁，ST-155）的中枢性降压机制的证据
Eur J Pharmacol. 1968 Feb;2(4):326-8. doi: 10.1016/0014-2999(68)90087-3.
4
The pharmacologic effects of ST-155 (Catapres) and related imidazolines in the rat.ST-155（可乐定）及相关咪唑啉类药物在大鼠体内的药理作用。
Pharmacology. 1969;2(6):337-51. doi: 10.1159/000136038.
5
Sites of central nervous action of clonidine on reflex autonomic function in the unanaesthetized rabbit.可乐定对未麻醉家兔反射性自主神经功能的中枢神经作用部位
Eur J Pharmacol. 1971 Jun;15(1):66-78. doi: 10.1016/0014-2999(71)90080-x.
6
Central cardiovascular effects of 6-hydroxydopamine.6-羟基多巴胺的中枢心血管效应。
Eur J Pharmacol. 1972 Nov;20(2):215-23. doi: 10.1016/0014-2999(72)90151-3.
7
Clonidine-induced cardiovascular effects after stereotaxic application in the hypothalamus of rats.大鼠下丘脑立体定位注射可乐定后的心血管效应。
J Pharm Pharmacol. 1972 May;24(5):410-1. doi: 10.1111/j.2042-7158.1972.tb09019.x.
8
Involvement of alpha-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurones.α受体在可乐定诱导的中枢单胺能神经元递质释放抑制中的作用。
Neuropharmacology. 1973 Nov;12(11):1073-80. doi: 10.1016/0028-3908(73)90051-8.
9
The central action of clonidine and its antagonism.可乐定的中枢作用及其拮抗作用。
Br J Pharmacol. 1972 Apr;44(4):779-87. doi: 10.1111/j.1476-5381.1972.tb07315.x.
10
Localization of the hypotenisve effect of 2-(2-6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155, Catapresan).2-(2,6-二氯苯基氨基)-2-咪唑啉盐酸盐（St 155，可乐宁）降压作用的定位
Eur J Pharmacol. 1969 Apr;6(1):8-12. doi: 10.1016/0014-2999(69)90057-0.

可乐定对猫血管运动中枢兴奋性的影响。

Effect of clonidine on the excitability of vasomotor loci in the cat.

作者信息

Dhawan B N, Johri M B, Singh G B, Srimal R C, Viswesaram D

出版信息

Br J Pharmacol. 1975 May;54(1):17-21. doi: 10.1111/j.1476-5381.1975.tb07404.x.

DOI:10.1111/j.1476-5381.1975.tb07404.x
PMID:1139074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666383/
Abstract
  1. The effect of clonidine on the direct excitability of hypothalamic, medullary and spinal vasomotor loci has been investigated in cats anaesthetized with chloralose. 2. Clonidine inhibited the excitability of these loci when it was localized to the central sites by intracerebroventricular, intravertebral arterial or intrathecal injection in very low doses (1-2 mug). 3. Topical application of clonidine (0.01 percent and 1.0 percent) to the floor of the fourth ventricle inhibited pressor responses evoked either by stimulation of medullary or hypothalamic vasomotor areas. Inhibition of the pressor responses was accompanied by hypotension and bradycardia in many experiments. 4. It appears that effects of clonidine on the vasomotor loci of the medulla oblongata and the spinal cord contribute to its hypotensive action.
摘要
  1. 已在用氯醛糖麻醉的猫身上研究了可乐定对下丘脑、延髓和脊髓血管运动位点直接兴奋性的影响。2. 当通过脑室内、椎动脉内或鞘内注射极低剂量（1 - 2微克）将可乐定定位到中枢部位时，它会抑制这些位点的兴奋性。3. 将可乐定（0.01%和1.0%）局部应用于第四脑室底部可抑制由刺激延髓或下丘脑血管运动区域引起的升压反应。在许多实验中，升压反应的抑制伴随着低血压和心动过缓。4. 看来可乐定对延髓和脊髓血管运动位点的作用有助于其降压作用。