Gulati K, Srimal R C, Dhawan B N
Pol J Pharmacol Pharm. 1978 Nov-Dec;30(6):811-8.
Effect of indoramin in small doses on the central vasomotor loci has been studied in chloralose anesthetized cats by localizing it to the central sites. An intracerebroventricular dose of 100 micrograms or intra-vertebral arterial injection of 50 micrograms significantly inhibited the excitability of hypothalamic and medullary vasomotor loci and produced hypotension. Similarly, topical application of indoramin (0.5%) to the floor of the IV ventricle inhibited the medullary and the hypothalamic vasomotor responses but a similar application to the ventral surface of the medulla had no effect. An intrathecal dose of 100 micrograms did not inhibit the spinal compression vasmotor response. Administration of higher amounts led to inhibition of the adrenaline pressor response also, indicating a peripheral leak of the drug. Indoramin has a definite inhibitory effect on the medullary vasomotor loci which contributes to the hypotension produced by this drug.
通过将吲哚拉明定位到中枢部位，研究了小剂量吲哚拉明对氯醛糖麻醉猫中枢血管运动位点的影响。脑室内注射100微克或椎动脉注射50微克可显著抑制下丘脑和延髓血管运动位点的兴奋性，并产生低血压。同样，将吲哚拉明（0.5%）局部应用于第四脑室底部可抑制延髓和下丘脑的血管运动反应，但将其类似地应用于延髓腹面则无效果。鞘内注射100微克不能抑制脊髓压迫血管运动反应。给予更高剂量也会导致肾上腺素升压反应受到抑制，表明药物出现外周渗漏。吲哚拉明对延髓血管运动位点具有明确的抑制作用，这是该药物产生低血压的原因之一。
