Lipski J, Solnicka E
Acta Physiol Pol. 1976 Jul-Aug;27(4):309-16.
The effect of i.v. administered clonidine (10-15 mug/kg) on the evoked potential recorded in the dosal part of medulla oblongata, during carotid sinus nerve stimulation, was studied in chloralose-urethane anaesthetized cats. Clonidine influenced the amplitude and configuration of the evoked potential and the changes were parallel to the blood pressure depressor response. However, the blood pressure drops, evoked by i.v. infusion of papaverine, did not influence the potential. It is concluded that the synaptic transmission from the carotid sinus nerve to the second order neurons in the solatary tract area can be modulated by the clonidine-induced activation of central adrenergic receptors.
在水合氯醛-乌拉坦麻醉的猫中，研究了静脉注射可乐定（10-15微克/千克）对在刺激颈动脉窦神经期间延髓背侧部分记录的诱发电位的影响。可乐定影响诱发电位的幅度和形态，且这些变化与血压降压反应平行。然而，静脉输注罂粟碱引起的血压下降并未影响该电位。得出的结论是，可乐定诱导的中枢肾上腺素能受体激活可调节从颈动脉窦神经到孤束核区域二级神经元的突触传递。
