Graham K A, Hoenich N A, Goodship T H
Gilbert Bain Hospital, Shetland, UK.
Int J Artif Organs. 2001 Apr;24(4):192-6.
In an observational study, nine hemodialysis patients using 35 mmol/l bicarbonate dialysate were studied over a 44-hour interdialytic interval. Serum bicarbonate was measured at regular intervals at home and the mean time averaged concentration was 27.0+/-1.2 mmol/l. Seven of the nine patients showed a slow linear decline in bicarbonate whilst in two patients levels were unchanged. In 8 of 9 patients the average of the post and predialysis bicarbonate accurately predicted the time-averaged (area under the curve) bicarbonate concentration. In addition, predialysis serum bicarbonate was measured in 46 patients after both a 2 and 3-day interdialytic interval. The serum bicarbonate was significantly lower after the 3-day interdialytic interval (3-day, 22.1+/-0.6 vs 2-day, 23.0+/-0.5 mmol/l, p<0.05). The results from this study emphasize the importance of standardization of bicarbonate measurement in order to avoid spurious acidosis.
在一项观察性研究中，对9名使用35mmol/L碳酸氢盐透析液的血液透析患者进行了44小时的透析间期研究。在家中定期测量血清碳酸氢盐，平均时间平均浓度为27.0±1.2mmol/L。9名患者中有7名患者的碳酸氢盐呈缓慢线性下降，而2名患者的水平未发生变化。9名患者中有8名患者透析后和透析前碳酸氢盐的平均值准确预测了时间平均（曲线下面积）碳酸氢盐浓度。此外，在46名患者透析间期为2天和3天后测量了透析前血清碳酸氢盐。透析间期为3天后血清碳酸氢盐显著降低（3天，22.1±0.6 vs 2天，23.0±0.5mmol/L，p<0.05）。这项研究的结果强调了碳酸氢盐测量标准化的重要性，以避免假性酸中毒。
