Retsas S, Christofyllakis C
Melanoma Unit Department of Medical Oncology Charing Cross Hospital London W6 8RF, U.K.
Anticancer Res. 2001 Mar-Apr;21(2B):1503-7.
We studied 19 patients, 12 males and 7 females of a median age of 49 years (range 26-76) with clinical manifestations of gastro-intestinal (GI) involvement from malignant melanoma. Their records were available from an electronic database of 2163 patients registered between 1977 and 1998 with the Melanoma Unit initially at Westminster and currently at Charing Cross Hospital. Time interval from initial presentation of melanoma to the development of GI involvement ranged from 6 to 183 months (median 44 months). Twelve patients had a laparotomy and in eight of these resection of metastatic sites was complete. Ten patients received systemic treatment. Median survival from GI involvement for patients who had resection of metastases was 21.5 months (range 1 to 253 months). Enterectomy, especially in the presence of solitary intestinal metastases, can palliate and may prolong survival. The role of adjuvant chemotherapy is less well defined but is worthy of consideration.
我们研究了19例患者，其中男性12例，女性7例，中位年龄49岁（范围26 - 76岁），均有恶性黑色素瘤累及胃肠道（GI）的临床表现。他们的记录来自一个电子数据库，该数据库收录了1977年至1998年间在黑色素瘤科室登记的2163例患者，该科室最初位于威斯敏斯特，目前位于查令十字医院。从黑色素瘤初次出现到胃肠道受累的时间间隔为6至183个月（中位时间44个月）。12例患者接受了剖腹手术，其中8例转移部位的切除是完整的。10例患者接受了全身治疗。接受转移灶切除的患者从胃肠道受累开始的中位生存期为21.5个月（范围1至253个月）。肠切除术，尤其是在存在孤立性肠转移的情况下，可以缓解症状并可能延长生存期。辅助化疗的作用尚不太明确，但值得考虑。
