Wang W, Zhu S Z, Pan L C, Hu A H, Wang Y H
Division of Neuropsychology, Anhui Institute of Stereotactic Neurosurgery, Anhui, China.
Funct Neurol. 2001 Jan-Mar;16(1):3-10.
The thalamo-(fronto)cortical circuit is involved in sleep regulation, and its dysfunction might contribute to the pathophysiology of chronic primary insomnia. To obtain more evidence of the involvement of the circuit, we studied 23 patients with chronic primary insomnia and 28 healthy volunteers via the assessment of mismatch negativity (MMN) elicited by tone intensity deviance, and of personality traits measured by Zuckerman's Sensation Seeking Scales, and Zuckerman-Kuhlman's Personality Questionnaire. In insomniacs, MMN amplitude at Fz was significantly larger; Depression, which was measured by Plutchik-van Praag's Depression Inventory, and Neuroticism-anxiety and Impulsivity scores were higher, while the Thrill and adventure seeking score was lower; MMN amplitude was positively correlated with Depression and with Impulsivity. In healthy subjects, MMN amplitude at Fz was positively correlated with Neuroticism-anxiety, but negatively with Experience seeking. The larger MMN and distinct personality traits suggest a hyperactivity in the thalamo-(fronto)cortical neuronal circuit in insomniacs, which is probably the result of weak thalamic gating mechanisms, or an imbalance of several neurotransmitter systems.
丘脑 - （额叶）皮质回路参与睡眠调节，其功能障碍可能导致慢性原发性失眠的病理生理过程。为了获得更多该回路参与其中的证据，我们通过评估由音调强度偏差引发的失配负波（MMN）以及用祖克曼感觉寻求量表和祖克曼 - 库尔曼人格问卷测量的人格特质，对23例慢性原发性失眠患者和28名健康志愿者进行了研究。在失眠症患者中，Fz处的MMN波幅显著更大；用普卢契克 - 范普拉格抑郁量表测量的抑郁、神经质 - 焦虑和冲动性得分更高，而刺激与冒险寻求得分更低；MMN波幅与抑郁和冲动性呈正相关。在健康受试者中，Fz处的MMN波幅与神经质 - 焦虑呈正相关，但与体验寻求呈负相关。更大的MMN和独特的人格特质表明失眠症患者丘脑 - （额叶）皮质神经元回路存在活动亢进，这可能是丘脑门控机制薄弱或几种神经递质系统失衡的结果。
