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孪生的机制。I. 环境多样性对单卵多胎妊娠中基因表达的影响。

Mechanisms of twinning. I. Effect of environmental diversity on genetic expression in monozygotic multifetal pregnancies.

作者信息

Steinman G

机构信息

Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.

出版信息

J Reprod Med. 2001 May;46(5):467-72.

PMID:11396374
Abstract

OBJECTIVE

To examine, using fingerprint homology, the interaction of genetic and environmental factors in arriving at the final phenotypic expression in uniovular triplets, quadruplets and quintuplets.

STUDY DESIGN

The fingerprints of several multifetal sets were collected and matched. A total of 250 fingers were printed. A comparison based on the classic dactylographic patterns was made. Zygosity of each set was known from placental chorionicity studies, as well as blood typing and physical similarities.

RESULTS

As the monozygotic set size increased, the ipsilateral print concordance diminished. At one extreme, with twins there is 88% homology; at the other end, with quintuplets the correspondence is 71%.

CONCLUSION

The overall trend of these results paralleled increasing intrauterine environmental diversity and tended to support the volar pad pressure hypothesis of prenatal fingerprint development.

摘要

目的

运用指纹同源性,研究单卵三胞胎、四胞胎和五胞胎在最终表型表达过程中基因和环境因素的相互作用。

研究设计

收集并匹配多个多胞胎组的指纹。共采集了250根手指的指纹。基于经典的指纹模式进行了比较。每组的合子性通过胎盘绒毛膜性研究、血型和身体相似性得以确定。

结果

随着单卵组规模的增加,同侧指纹一致性降低。一方面,双胞胎的同源性为88%;另一方面,五胞胎的对应率为71%。

结论

这些结果的总体趋势与子宫内环境多样性的增加相一致,倾向于支持产前指纹发育的掌垫压力假说。

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引用本文的文献

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The Prenatal Environment in Twin Studies: A Review on Chorionicity.双胎研究中的产前环境:关于绒毛膜性的综述
Behav Genet. 2016 May;46(3):286-303. doi: 10.1007/s10519-016-9782-6. Epub 2016 Mar 5.