Carroll Stephen G M, Tyfield Linda, Reeve Louise, Porter Helen, Soothill Peter, Kyle Phillipa Mm
St Michael's Hospital, Bristol, United Kingdom.
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):757-61. doi: 10.1016/j.ajog.2005.01.024.
The purpose of this study was to examine whether fetal outcome in twin pregnancies is dependent on zygosity or chorionicity.
This was a prospective observational study comprised of women with twin pregnancies who attended the fetal medicine unit at St Michael's Hospital, Bristol, Ireland, during the years 1998 to 2000 and who were delivered in hospitals in south west England. After delivery, zygosity was determined with umbilical cord blood with the use of microsatellite markers that were amplified by polymerase chain reaction. Placentae were examined histologically for chorionic type. The perinatal outcomes of 3 groups of monozygotic monochorionic, monozygotic dichorionic, and dizygotic pregnancies were compared with the use of the Mann-Whitney U test and the Fisher's exact test.
All 92 dizygotic and 15 monozygotic dichorionic pregnancies resulted in live births. In 7 of the 39 cases in the monozygotic monochorionic group, either both twins were not live born or delivery occurred <24 weeks of gestation. The gestational age at delivery and birth weight were significantly lower, and there were a greater number of cases with birth weight discordancy of >25% in the monochorionic pregnancies compared with the other 2 groups (P < .05). There were no significant differences in any of the study parameters between the monozygotic dichorionic and dizygotic groups.
Fetal outcome in twin pregnancies is related to chorionicity rather than zygosity.
本研究旨在探讨双胎妊娠的胎儿结局是否取决于合子性或绒毛膜性。
这是一项前瞻性观察性研究，研究对象为1998年至2000年期间在爱尔兰布里斯托尔圣迈克尔医院胎儿医学科就诊且在英格兰西南部医院分娩的双胎妊娠妇女。分娩后，使用聚合酶链反应扩增的微卫星标记物对脐带血进行合子性检测。对胎盘进行组织学检查以确定绒毛膜类型。使用曼-惠特尼U检验和费舍尔精确检验比较单卵单绒毛膜、单卵双绒毛膜和双卵妊娠3组的围产期结局。
所有92例双卵妊娠和15例单卵双绒毛膜妊娠均分娩活婴。在单卵单绒毛膜组的39例病例中，有7例出现双胎均未存活或分娩发生在妊娠<24周。与其他2组相比，单绒毛膜妊娠的分娩孕周和出生体重显著较低，且出生体重差异>25%的病例数更多（P<.05）。单卵双绒毛膜组和双卵组之间的任何研究参数均无显著差异。
双胎妊娠的胎儿结局与绒毛膜性有关，而非合子性有关
