Hughes K, Meek M E, Walker M
Environmental Health Directorate, Health Canada, Tunney's Pasture PL0802B1, Ottawa, Ontario, Canada K1A 0L2.
Chem Biol Interact. 2001 Jun 1;135-136:109-35. doi: 10.1016/s0009-2797(01)00173-9.
1,3-Butadiene was included in the second list of Priority Substances to be assessed under the Canadian Environmental Protection Act. Potential hazards to human health were characterized on the basis of critical examination of available data on health effects in experimental animals and occupationally exposed human populations, as well as information on mode of action. Based on consideration of all relevant data identified as of April 1998, butadiene was considered highly likely to be carcinogenic to humans, and likely to be a somatic and germ cell genotoxicant in humans. In addition, butadiene may also be a reproductive toxicant in humans. Estimates of the potency of butadiene to induce these effects have been derived on the basis of quantitation of observed exposure-response relationships for the purposes of characterization of risk to the general population in Canada exposed to butadiene in the ambient environment.
1,3 - 丁二烯被列入根据《加拿大环境保护法》进行评估的第二批优先物质清单。基于对实验动物和职业暴露人群健康影响的现有数据以及作用模式信息的严格审查，对人类健康的潜在危害进行了特征描述。基于对截至1998年4月所确定的所有相关数据的考虑，丁二烯被认为极有可能对人类致癌，并且可能是人类体细胞和生殖细胞的基因毒性物质。此外，丁二烯在人类中也可能是一种生殖毒性物质。为了对加拿大环境中接触丁二烯的普通人群的风险进行特征描述，已根据观察到的暴露 - 反应关系的定量分析得出丁二烯诱发这些影响的效力估计值。
