Giudicelli Y, Pecquery R, Magyar C, Lacasa M, Nordmann R
Clin Chim Acta. 1975 May 1;60(3):335-46. doi: 10.1016/0009-8981(75)90076-5.
The phospholipids in tracheal aspirates from normal full term newborn infants were studied and compared to the phospholipids present in the corresponding amniotic fluids. The same classes of phospholipids were recovered from both fluids, i.e. lysophosphatidylcholine (LPC), phosphatidylserine (PS), phosphatidylinositol (PI), sphingomyelin (S), phosphatidyldimethylethanolamine (PDME), phosphatidylethanolamine (PE), polyglycerophosphatides (PGP), phosphatidic acids (PA) and two different species of phosphatidylcholine (PC-1 and PC-2). Except for PA, the proportion as well as the fatty acid composition of each of these phospholipids was similar in tracheal aspirates and in amniotic fluids. The predominant fraction (PC-1) was the most saturated one. PI, PDME, LPC and S were, like PC-1, predominantly constituted by saturated fatty acids and accounted together for a concentration equivalent to that of PC-1. Since tracheal aspirate originates from the lung, these data suggest that the pulmonary surfactant activity in normal full term newborn infants results not only from the presence of PC-1, but also from that of PI, PDME, LPC and S.
对正常足月新生儿气管吸出物中的磷脂进行了研究，并与相应羊水所含的磷脂进行了比较。两种液体中回收的磷脂种类相同，即溶血磷脂酰胆碱（LPC）、磷脂酰丝氨酸（PS）、磷脂酰肌醇（PI）、鞘磷脂（S）、磷脂酰二甲基乙醇胺（PDME）、磷脂酰乙醇胺（PE）、聚甘油磷脂（PGP）、磷脂酸（PA）以及两种不同的磷脂酰胆碱（PC - 1和PC - 2）。除PA外，气管吸出物和羊水中这些磷脂各自的比例以及脂肪酸组成相似。主要部分（PC - 1）是饱和度最高的一种。PI、PDME、LPC和S与PC - 1一样，主要由饱和脂肪酸构成，它们的浓度总和与PC - 1相当。由于气管吸出物源自肺部，这些数据表明正常足月新生儿的肺表面活性物质活性不仅源于PC - 1的存在，还源于PI、PDME、LPC和S的存在。
