Chevalier X, Conrozier T, Gehrmann M, Claudepierre P, Mathieu P, Unger S, Vignon E
Department of Rheumatology, Hôpital Henri-Mondor, Université de Paris XII, Creteil, France.
Osteoarthritis Cartilage. 2001 May;9(4):300-7. doi: 10.1053/joca.2000.0389.
To determine the predictive value of serum levels of TIMP-1 and hyaluronic acid in a 1 year prospective study in hip osteoarthritis (OA).
Twenty-nine patients with OA of the hip were enrolled in a 1-year prospective study (median follow-up, 13 months). Biochemical analysis was used to assess TIMP-1 and hyaluronic acid at entry and at the end of the study. Radiographic evaluation with an assisted computed program was performed to calculate progression of joint space narrowing. Statistical tests served to determine correlations between observed serum levels and radiograph joint space narrowing.
Among the 29 patients, 10 showed joint space narrowing greater than 0.6 mm per year. The initial concentration of TIMP-1 as well as delta value of variation in serum levels of TIMP-1 (difference between TIMP-1 concentration at entry and at the end) correlated with the progression of joint space narrowing. A cut-off value of 600 ng/ml of TIMP-1 allowed the patients who progressed slowly from those who progressed more rapidly. Hyaluronic acid serum level was not predictive of evolution.
TIMP-1 serum level may serve to predict the evolution of patients with hip OA.
在一项针对髋骨关节炎（OA）的1年前瞻性研究中，确定血清中基质金属蛋白酶组织抑制因子-1（TIMP-1）和透明质酸水平的预测价值。
29例髋OA患者纳入一项为期1年的前瞻性研究（中位随访时间为13个月）。在研究开始时和结束时，采用生化分析评估TIMP-1和透明质酸水平。使用辅助计算机程序进行影像学评估，以计算关节间隙狭窄的进展情况。通过统计检验确定观察到的血清水平与X线片关节间隙狭窄之间的相关性。
29例患者中，10例患者的关节间隙每年狭窄超过0.6 mm。TIMP-1的初始浓度以及TIMP-1血清水平的变化差值（研究开始时与结束时TIMP-1浓度的差值）与关节间隙狭窄的进展相关。TIMP-1浓度为600 ng/ml的临界值可区分进展缓慢的患者与进展较快的患者。透明质酸血清水平不能预测病情发展。
TIMP-1血清水平可用于预测髋OA患者的病情发展。
