Sharif M, George E, Shepstone L, Knudson W, Thonar E J, Cushnaghan J, Dieppe P
University of Bristol, Department of Medicine, Bristol Royal Infirmary, UK.
Arthritis Rheum. 1995 Jun;38(6):760-7. doi: 10.1002/art.1780380608.
To investigate the prognostic value of serum hyaluronic acid (HA) and keratan sulfate (KS) levels in relation to tibiofemoral osteoarthritis (OA) of the knee.
Clinical and demographic data were collected on 94 patients. Radiographs were obtained at study entry and at 5-year followup. Disease progression was defined as 2 mm of joint space narrowing of any tibiofemoral compartment, and/or knee joint surgery during the study period. Serum HA and KS were measured and levels were correlated with entry data and disease progression.
At entry, HA levels were significantly related to disease duration (P = 0.036), minimum joint space (P = 0.049), and previous surgery (P = 0.001). After these variables were taken into account, patients whose disease had progressed were shown to have had significantly higher levels of HA at baseline compared with those whose disease had not progressed (P = 0.019). However, there were no significant differences in levels of serum KS between those with and those without disease progression, at entry (P = 0.779) or at subsequent visits.
These results suggest that serum HA levels predict disease outcome in OA of the knee and confirm that a single measurement of the serum level of KS is not useful as a prognostic marker in OA.
探讨血清透明质酸（HA）和硫酸角质素（KS）水平对膝胫股关节炎（OA）的预后价值。
收集94例患者的临床和人口统计学数据。在研究开始时和5年随访时拍摄X线片。疾病进展定义为在研究期间任何胫股关节间隙狭窄2mm和/或进行膝关节手术。检测血清HA和KS水平，并将其与初始数据和疾病进展情况相关联。
在研究开始时，HA水平与疾病持续时间（P = 0.036）、最小关节间隙（P = 0.049）和既往手术史（P = 0.001）显著相关。在考虑这些变量后，与疾病未进展的患者相比，疾病进展的患者在基线时HA水平显著更高（P = 0.019）。然而，疾病进展组和未进展组在研究开始时（P = 0.779）及后续随访时血清KS水平均无显著差异。
这些结果表明，血清HA水平可预测膝骨关节炎的疾病转归，并证实单次检测血清KS水平作为骨关节炎的预后标志物并无用处。
