Bruijnzeel A W, Stam R, Croiset G, Wiegant V M
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, Netherlands.
Physiol Behav. 2001 May;73(1-2):81-6. doi: 10.1016/s0031-9384(01)00435-8.
There is evidence that the experience of traumatic events may play a role in the pathogenesis of somatic diseases, including cardiovascular disorders. In this study, telemetry was used to investigate the long-term effects of a single stressful experience on cardiovascular and behavioral responses to novel challenges 2 weeks later. Rats were exposed to footshocks and tested for sensitization using the following challenges: novel cylinder (Day 14); shock prod acquisition test (Day 15); and shock prod retention test (Day 16). No difference in basal somatomotor activity (SA), heart rate (HR) and blood pressure between preshocked rats and control rats was found. However, preshocked rats displayed an enhanced blood pressure response compared to controls during the shock prod acquisition test and the shock prod retention test. No differential increase in HR response between both groups was found. During the novel cylinder test, the preshocked rats displayed less SA while no behavioral differences were found in the shock prod acquisition test and the shock prod retention test. We conclude that a single stressful experience induces long-term sensitization of blood pressure responses to novel challenges that are not necessarily linked to sensitized behavioral responses. The footshock model may be a useful model to study autonomic hyperresponsivity found in posttraumatic stress disorder (PTSD).
有证据表明，创伤性事件的经历可能在包括心血管疾病在内的躯体疾病的发病机制中起作用。在本研究中，使用遥测技术来研究单次应激经历对2周后心血管和行为对新挑战反应的长期影响。将大鼠暴露于足底电击，并使用以下挑战测试敏化作用：新奇圆筒试验（第14天）；电击棒习得试验（第15天）；以及电击棒保持试验（第16天）。未发现遭受电击前的大鼠与对照大鼠在基础躯体运动活动（SA）、心率（HR）和血压方面存在差异。然而，在电击棒习得试验和电击棒保持试验期间，与对照组相比，遭受电击前的大鼠表现出增强的血压反应。两组之间未发现HR反应的差异增加。在新奇圆筒试验期间，遭受电击前的大鼠表现出较少的SA，而在电击棒习得试验和电击棒保持试验中未发现行为差异。我们得出结论，单次应激经历会诱导对新挑战的血压反应长期敏化，而这不一定与敏化的行为反应相关。足底电击模型可能是研究创伤后应激障碍（PTSD）中发现的自主神经高反应性的有用模型。
