诺氟沙星曼尼希碱与异吲哚酮衍生物的抗结核活性
Antituberculous activity of norfloxacin mannich bases with isatin derivatives.
作者信息
Pandeya S N, Sriram D, Yogeeswari P, Ananthan S
机构信息
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
出版信息
Chemotherapy. 2001 Jul-Aug;47(4):266-9. doi: 10.1159/000048533.
Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37R(v) at 12.5 microg/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower than 6.25 microg/ml.
通过将诺氟沙星与甲醛及几种异吲哚酮衍生物反应合成了其曼尼希碱。使用BACTEC辐射测量系统，在BACTEC 12B培养基中以12.5微克/毫升的浓度对这些化合物进行了体外抗结核分枝杆菌H37R(v)活性评估。在所测试的化合物中，S-10表现出良好的活性，在浓度低于6.25微克/毫升时抑制率达100%。
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