Di Crecchio L, Parodi M B, Saviano S, Ravalico G
Eye Clinic, University of Trieste, Trieste, Italy.
Acta Ophthalmol Scand. 2001 Jun;79(3):319-21. doi: 10.1034/j.1600-0420.2001.790324.x.
To report a case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) in the course of Ulcerative Colitis (UC).
A complete ophthalmologic evaluation, including fluorescein and indocyanine green angiography, was performed.
A patient with exacerbation of UC was referred to our department for sudden visual loss in RE. Ophthalmoscopy disclosed multifocal yellow-white placoid lesions typical of APMPPE in RE. There were no lesions in the fellow eye. On fluorescein angiography (FA), the active lesions showed early hypofluorescence, followed by late staining. Indocyanine green angiography (ICGA) revealed early and late hypofluorescence corresponding to the lesions observed clinically, and late anular staining surrounding a hypofluorescent lesion at the posterior pole. On LE ICGA revealed lesions not detected with ophthalmoscopy and FA. After corticosteroid therapy the lesions healed.
Ulcerative Colitis may be responsible for the onset of AMPPPE by an immunological mechanism of delayed type hypersensitivity reaction.
报告1例溃疡性结肠炎（UC）病程中出现急性后极部多灶性扁平色素上皮病变（APMPPE）的病例。
进行了包括荧光素和吲哚菁绿血管造影在内的全面眼科评估。
1例UC病情加重的患者因右眼突然视力丧失转诊至我科。眼底检查发现右眼有典型的APMPPE多灶性黄白色扁平病变。对侧眼无病变。在荧光素血管造影（FA）中，活动性病变早期表现为低荧光，随后晚期染色。吲哚菁绿血管造影（ICGA）显示与临床观察到的病变相对应的早期和晚期低荧光，以及后极部低荧光病变周围的晚期环状染色。左眼ICGA显示眼底检查和FA未发现的病变。皮质类固醇治疗后病变愈合。
溃疡性结肠炎可能通过迟发型超敏反应的免疫机制导致AMPPPE的发生。
