Fonseca E, Peña C, Del Pozo J, Almagro M, Yebra M T, Cuevas J, Contreras F
Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain.
J Cutan Pathol. 2001 May;28(5):271-5. doi: 10.1034/j.1600-0560.2001.028005271.x.
Olmsted syndrome is an uncommon inherited disorder of keratinization that presents mutilating palmoplantar keratoderma, perioral hyperkeratosis, leukokeratosis and alopecia. We report a case of this rare syndrome diagnosed in a 48-year-old woman and confirms the existence of a generalized abnormality in keratin expression. Immunoreactivity in our case suggests an abnormal expression of keratins 5 and 14 similar to the observed in other hyperproliferative disorders.
奥姆斯特德综合征是一种罕见的角化遗传性疾病，表现为致残性掌跖角化病、口周角化过度、白色角化病和脱发。我们报告了一例在一名48岁女性中诊断出的这种罕见综合征病例，并证实了角蛋白表达存在全身性异常。我们病例中的免疫反应性表明角蛋白5和14的表达异常，类似于在其他增殖性疾病中观察到的情况。
