Aho A J, Linna M I
Eur Surg Res. 1975;7(2):91-100. doi: 10.1159/000127795.
In experimental small bowel obstruction an increased proportion of smooth endoplasmic reticulum and an increased number of lysosomes were seen in many liver cells. The occurrence of cytoplasmic vacuoles as well as the glycogen depletion were not pathognomonic and in the toxic pathogenesis the ultrastructural damage in the liver was only of a low degree and can be explained as a reactive (e.g. detoxication) phenomenon. The increase of plasma corticosterone content (stress reaction) differed only slightly from that of the controls, but a severe disturbance of fluid balance (increase of hematocrit and decrease of serum Na+ and C1-) and circulation failure were the more conspicuous findings, compared to toxic liver cell disturbance in the pathogenesis of small bowel obstruction.
在实验性小肠梗阻中，许多肝细胞内滑面内质网比例增加，溶酶体数量增多。细胞质空泡的出现以及糖原耗竭并非特异性表现，在中毒性发病机制中，肝脏的超微结构损伤程度较低，可解释为一种反应性（如解毒）现象。血浆皮质酮含量的增加（应激反应）与对照组相比仅有轻微差异，但与小肠梗阻发病机制中的毒性肝细胞损伤相比，更为明显的发现是严重的体液平衡紊乱（血细胞比容升高、血清钠和氯降低）和循环衰竭。
