抗菌药物对真菌疗效的体外研究。

In vitro studies of the efficacy of antimicrobials against fungi.

作者信息

Meiller T F, Kelley J I, Jabra-Rizk M A, Depaola L G, Baqui A A, Falkler W A

机构信息

Department of Oral Medicine and Diagnostic Sciences, Unversity of Maryland Dental School, Balitmore, Md 21201, USA.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun;91(6):663-70. doi: 10.1067/moe.2001.113550.

DOI:10.1067/moe.2001.113550

PMID:11402279

Abstract

OBJECTIVE

The purpose of this study was to compare the efficacy of Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses and a 0.2% chlorhexidine digluconate solution against known pathogenic fungi.

STUDY DESIGN

Standardized methods were used to compare the antimicrobial efficacy of the above agents versus representative fungal species. Minimum inhibitory concentration-minimum fungicidal concentrations in macrobroth dilutions, suspension kill-time, and effectiveness against an artificial biofilm-attached population were studied.

RESULTS

All antimicrobials tested were effective against the fungal species under investigation at the concentration available commercially. Listerine Antiseptic showed a greater efficacy against attached artificial biofilm populations than the other antimicrobials tested.

CONCLUSIONS

Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses show promise as a means to control the pathogenic fungal species under investigation and may have applications to reduce oral colonization.

摘要