Maziere Marie, Rompante Paulo, Andrade José Carlos, Rodrigues Célia F
UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal.
Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, Avenida Central de Gandra 1317, 4585-116 Gandra, Portugal.
J Fungi (Basel). 2024 Jul 29;10(8):528. doi: 10.3390/jof10080528.
Oral candidiasis is an opportunistic infection caused by fungi of the genus . Nystatin, fluconazole, and miconazole are the most widely used antifungal drugs in dentistry, but in recent years, they have been shown to be less effective due to the increase in the resistance to antifungal drugs. The growing challenge of antifungal resistance emphasizes the importance of exploring not only alternative strategies in the fight against spp. infections but also supportive treatment for pharmacological treatment for oral candidiasis. This review aims to evaluate and compare the in vitro reports on antifungal efficacy against spp. exhibited by mouthwashes distributed on the European market. The research question was elaborated through the PEO framework recommended by PRISMA 2020. A bibliographic search strategy was developed for the scientific online databases Pubmed and ScienceDirect. According to the eligibility criteria, 21 papers were included in this study over a 27-year period. Mouthwashes containing chlorhexidine digluconate, cetylpyridinium chloride, hexetidine, and fluorine compounds among others, and natural antimicrobials, such as menthol, thymol, eucalyptol, and extracts, have demonstrated antifungal effectiveness. Nonetheless, the methodological variance introduces ambiguity concerning the comparative efficacy of distinct molecules or mouthwash formulations and complicates the evaluation and the comparison of results between studies. Some mouthwashes commercially available in Europe have the potential to be used in anti- therapy and prevention since they have shown antifungal effect.
口腔念珠菌病是由念珠菌属真菌引起的一种机会性感染。制霉菌素、氟康唑和咪康唑是牙科领域使用最广泛的抗真菌药物，但近年来，由于抗真菌药物耐药性的增加，它们的效果已不如从前。抗真菌耐药性这一日益严峻的挑战凸显了不仅要探索对抗念珠菌属感染的替代策略，还要为口腔念珠菌病的药物治疗提供支持性治疗的重要性。本综述旨在评估和比较欧洲市场上销售的漱口水对念珠菌属的体外抗真菌疗效报告。通过PRISMA 2020推荐的PEO框架阐述了研究问题。为科学在线数据库PubMed和ScienceDirect制定了文献检索策略。根据纳入标准，在27年的时间里，本研究共纳入了21篇论文。含有葡萄糖酸氯己定、西吡氯铵、己脒定和氟化合物等的漱口水，以及薄荷醇、百里酚、桉叶油和提取物等天然抗菌剂，均已证明具有抗真菌效果。尽管如此，方法学上的差异导致不同分子或漱口水配方的比较疗效存在模糊性，也使研究结果的评估和比较变得复杂。欧洲市场上一些市售漱口水已显示出抗真菌作用，因此有潜力用于抗念珠菌治疗和预防。
