Homan W L, Mank T G
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
Int J Parasitol. 2001 Jun;31(8):822-6. doi: 10.1016/s0020-7519(01)00183-7.
Giardia duodenalis infection in humans can cause a variety of clinical symptoms. The relation between clinical symptomatology and the Giardia isolate genotype was studied in 18 Dutch patients infected with G. duodenalis who visited their general practitioner. Contrary to earlier studies, a 100% correlation between severity of diarrhoeal complaints and genotype was found: assemblage A isolates were solely detected in patients with intermittent diarrhoeal complaints, while assemblage B isolates were present in patients with persistent diarrhoeal complaints. These results are significant because they show for the first time that genetically linked features of G. duodenalis are major determinants in the severity of infection in human giardiasis.
人感染十二指肠贾第虫可引发多种临床症状。对18名感染十二指肠贾第虫并前往全科医生处就诊的荷兰患者，研究了临床症状与贾第虫分离株基因型之间的关系。与早期研究相反，发现腹泻症状严重程度与基因型之间存在100%的相关性：仅在间歇性腹泻患者中检测到A群分离株，而持续性腹泻患者中存在B群分离株。这些结果意义重大，因为它们首次表明，十二指肠贾第虫的基因相关特征是人类贾第虫病感染严重程度的主要决定因素。
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