The relationship of oxidative DNA damage marker 8-hydroxydeoxyguanosine and glycoxidative damage marker pentosidine.
作者信息
Kouda K, Nakamura H, Fan W, Horiuchi K, Takeuchi H
机构信息
Department of Public Health, Hamamatsu University School of Medicine, Hamamatsu, Japan.
出版信息
Clin Biochem. 2001 May;34(3):247-50. doi: 10.1016/s0009-9120(01)00201-6.
OBJECTIVES
8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. Pentosidine is a biomarker of glycoxidation reaction. In this study, we investigated relationships among 8-OHdG, pentosidine and age.
DESIGN AND METHODS
We determined the urinary concentrations of 8-OHdG and pentosidine in adults with mild hypercholesterolemia or/and mild hypertension (hypercholesterolemia group, n = 31; hypertension group, n = 25; hypercholesterolemia and hypertension group, n = 7).
RESULTS
The strength of the relationship between 8-OHdG and age was the same as that between pentosidine and age (the correlation coefficient between 8-OHdG and age was 0.33, pentosidine and age was 0.37). In addition, there was a positive and significant correlation between 8-OHdG and pentosidine. On the other hand, mean values of 8-OHdG and pentosidine showed no significant difference among the three groups.
CONCLUSION
The results of the present study indicate that both 8-OHdG and pentosidine levels increase similarly in degenerative pathologic conditions.
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