脂质偶联蛋白在肠道中的免疫原性。
Immunogenicity of lipid-conjugated protein in the intestine.
作者信息
Heatley R V, Stark J M
出版信息
Immunology. 1975 Jul;29(1):143-9.
Abstract
Acylation of human serum albumin increases its ability to stimulate antibody formation in rats. This can be shown not only when the antigen was given intramuscularly but also when administered by injection into the lumen of the gut. A tendency of the modified molecules to attach to cells and to aggregate, increased anti-complementary activity, and reduced drainage through the lymphatics, have been demonstrated. The relationship of these features to the increased immunogenicity is discussed.
摘要
人血清白蛋白的酰化作用增强了其刺激大鼠抗体形成的能力。这不仅在抗原通过肌肉注射给予时得到证实，而且在通过注射到肠腔内给予时也得到证实。已证明修饰分子具有附着于细胞并聚集的倾向、增强的抗补体活性以及通过淋巴管的引流减少。讨论了这些特征与免疫原性增加之间的关系。
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