Stark J M, Matthews N, Locke J
Immunology. 1980 Mar;39(3):353-60.
The most immunogenic of various acylated human serum albumin (HSA) preparations also showed the greatest anti-complementary activity. This is due in part to their ability to activate the alternative pathway and consume complement components. Such molecules also adsorbed radiolabelled complement components readily and were themselves rapidly removed from the circulation after their intravenous injection. Highly lipidated C14 HSA (C14, fatty acid side-chains with 14 carbon atoms) was not itself mitogenic: unlike HSA it localized heavily to the red pulp as well as to cells of dendritic form in the splenic white pulp. The increased immunogenicity is found in lipidated HSA species which show the following features: hydrophobicity, anti-complementary activity, ability to activate complement, heavy localization in the red pulp and an unusual tendency to localize to dendritic cells of the while pulp.
各种酰化人血清白蛋白（HSA）制剂中免疫原性最强的制剂也表现出最大的抗补体活性。这部分归因于它们激活替代途径和消耗补体成分的能力。这类分子还能轻易吸附放射性标记的补体成分，并且在静脉注射后自身会迅速从循环中清除。高度脂化的C14 HSA（C14，具有14个碳原子的脂肪酸侧链）本身没有促有丝分裂作用：与HSA不同，它大量定位于脾红髓以及脾白髓中的树突状细胞。在具有以下特征的脂化HSA种类中发现了免疫原性增强的情况：疏水性、抗补体活性、激活补体的能力、在红髓中的大量定位以及定位于白髓树突状细胞的异常倾向。
