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The effect of chronic lithium application on the mineral content of rat bone and soft tissues.

作者信息

Bellwinkel S, Schäfer A, Minne H, Ziegler R

出版信息

Int Pharmacopsychiatry. 1975;10(1):9-16. doi: 10.1159/000468163.

DOI:10.1159/000468163
PMID:1140905
Abstract

Rats were treated with lithium chloride over 6 weeks. During the experiment, determinations of serum calcium, magnesium and phosphorus revealed no changes due to the therapy. Postmortem examinations of liver, skeletal muscle, and femur minerals as well as bone histology showed these organs to be unaffected by lithium application. Only body weight gain was in part increased by lithium.

摘要

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice.氯化锂通过不依赖Lrp5的方式激活Wnt信号通路,增加小鼠的骨形成和骨量。
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17406-11. doi: 10.1073/pnas.0505259102. Epub 2005 Nov 17.
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Lithium inhibition of bone mineralization and osteoid formation.
锂对骨矿化和类骨质形成的抑制作用。
J Clin Invest. 1978 Jun;61(6):1691-6. doi: 10.1172/JCI109090.