Meyer J L, Smith L H
Invest Urol. 1975 Jul;13(1):31-5.
The kinetics of the crystal growth of calcium oxalate monohydrate has been studied using the technique of seeded crystal growth from stable supersaturated solution. The rate law takes the form minus dc/dt equals kN-2 in which the rate of loss of lattice ion from solution is proportional to the square of the supersaturation. It is proposed that the incorporation of lattice ions into the crystal is governed by a bimolecular surface-controlled reaction step. The rate is independent of the hydrodynamics of the system but is proportional to the solid to solution ratio in the supersaturated solution. The specific rate constant, k (M-minus-1 min-minus-1 [mg/dl]minus-1), is nearly independent of the solid to solution ratio, however. The rate of crystal growth was found not to vary with the calcium to oxalate molar ratio in the range 1.5 to 0.75, although the rate did increase at both higher and lower ratios. The method was found to be simple, rapid, and reproducible and lends itself to the quantitative study of inhibitors of crystal growth.
已采用从稳定过饱和溶液中进行晶种生长的技术研究了一水合草酸钙晶体生长的动力学。速率定律的形式为 -dc/dt = kN⁻²，其中晶格离子从溶液中损失的速率与过饱和度的平方成正比。有人提出晶格离子掺入晶体是由双分子表面控制的反应步骤所支配。该速率与系统的流体动力学无关，但与过饱和溶液中的固液比成正比。然而，比速率常数k（M⁻¹ min⁻¹ [mg/dl]⁻¹）几乎与固液比无关。尽管在较高和较低比例下速率确实增加，但发现晶体生长速率在1.5至0.75的钙与草酸盐摩尔比范围内不随其变化。该方法被发现简单、快速且可重复，适用于晶体生长抑制剂的定量研究。
