Myers B D, Klajman A
Isr J Med Sci. 1975 Apr;11(4):335-9.
Following acceptance to a renal dialysis therapy program, 13 patients underwent serial examination of the serum complement system for periods of 6 to 12 months. Serum levels of C3 and C4 were examined at monthly intervals before the first dialysis of each month. The patients suffered from various primary renal diseases, including glomerulonephritis, obstructive uropathy with chronic pyelonephritis, nephrosclerosis and chronic nephropathy of undetermined nature. Levels of serum C3 were depressed at some time during the study period in all patients. Serum C4 levels were normal. The depression of serum C3 levels was significant and prolonged in nine patients. There seemed to be no relationship between the nature of the basic disease and the depression of serum C3 levels. Caution should be exercised in attributing depressed C3 levels to a particular type of underlying renal disease in patients on renal dialysis.
13名患者在被接受进入肾透析治疗项目后，进行了为期6至12个月的血清补体系统系列检查。在每月第一次透析前，每月检测血清C3和C4水平。这些患者患有各种原发性肾脏疾病，包括肾小球肾炎、伴有慢性肾盂肾炎的梗阻性尿路病、肾硬化症以及性质未明的慢性肾病。在研究期间，所有患者的血清C3水平在某些时候均有所降低。血清C4水平正常。9名患者的血清C3水平显著且持续降低。基础疾病的性质与血清C3水平降低之间似乎没有关联。对于接受肾透析的患者，在将C3水平降低归因于特定类型的潜在肾脏疾病时应谨慎。
