Nickel J C, True L D, Krieger J N, Berger R E, Boag A H, Young I D
Department of Urology, Queen's University, Kingston, Ontario, Canada.
BJU Int. 2001 Jun;87(9):797-805. doi: 10.1046/j.1464-410x.2001.02193.x.
To develop a standardized histopathological classification system for chronic prostatitis (standardized description of prostatic inflammatory infiltrates) based on a literature review, extensive prospective evaluations in two recognized prostatitis research centres and widespread consensus of international urological centres identified as having major expertise or interest in chronic prostatitis.
Relevant articles for review were identified by a Medline search undertaken by the Cochrane Review Group in Prostate Diseases and Urologic Malignancies, and cross-checking bibliographies of retrieved studies, reviews, book chapters and abstracts of the American Urological Association and International Prostatitis Collaborative Network Annual Meetings. Initial drafts were based on classification systems independently developed by the Prostatitis Research Centers at Queen's University in Canada and University of Washington in the USA. A collaborative draft was distributed to 20 urological/pathological clinical centres who participated in the North American Chronic Prostatitis Collaborative Research Network and First International Prostatitis Collaborative Network. A consensus classification system was then distributed to the participating panel for acceptance.
The literature review identified a reasonably consistent description of inflammatory infiltrate locations and patterns that were further incorporated into the draft based on the Queen's University and University of Washington proposals. Eighteen (90%) of the identified Prostatitis Centers participated in the revision of the draft and the final consensus process. The final consensus document classifies prostatic inflammation according to its extent and grade/severity in each tissue compartment (location). Conclusion The consensus of the expert panel was that this classification system can be used in the evaluation of prostatic inflammation in prostate biopsies, transurethral resected prostate chips or prostatectomy specimens. A standardized accepted framework to describe histopathological prostate inflammation will prove useful in evaluating prostate disease.
基于文献综述、在两个知名前列腺炎研究中心进行的广泛前瞻性评估以及被认定在慢性前列腺炎方面具有主要专业知识或兴趣的国际泌尿学中心的广泛共识，制定一种慢性前列腺炎的标准化组织病理学分类系统（前列腺炎性浸润的标准化描述）。
通过前列腺疾病和泌尿生殖系统恶性肿瘤领域的Cochrane综述小组进行的Medline检索，以及交叉核对检索到的研究、综述、书籍章节以及美国泌尿外科学会和国际前列腺炎协作网络年会的摘要的参考文献，来确定相关的综述文章。初稿基于加拿大女王大学和美国华盛顿大学前列腺炎研究中心独立开发的分类系统。一份协作草案分发给了20个参与北美慢性前列腺炎协作研究网络和第一届国际前列腺炎协作网络的泌尿学/病理学临床中心。然后将一份共识分类系统分发给参与小组以供接受。
文献综述确定了炎性浸润部位和模式的合理一致描述，这些描述基于女王大学和华盛顿大学的提议进一步纳入草案。确定的18个（90%）前列腺炎中心参与了草案的修订和最终共识过程。最终的共识文件根据前列腺炎症在每个组织区域（位置）的范围和分级/严重程度对其进行分类。结论专家小组的共识是，该分类系统可用于评估前列腺活检、经尿道前列腺切除组织碎片或前列腺切除标本中的前列腺炎症。一个用于描述前列腺组织病理学炎症的标准化公认框架将被证明对评估前列腺疾病有用。
