Hu Jimeng, Zhang Limin, Zou Lujia, Hu Mengbo, Fan Jie, Cai Yehua, Xu Gang, Fang Jie, Ding Qiang, Jiang Haowen
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Int J Urol. 2015 Dec;22(12):1138-42. doi: 10.1111/iju.12914. Epub 2015 Aug 27.
To explore whether asymptomatic inflammatory prostatitis is associated with prostatic enlargement beyond that of benign prostatic hyperplasia patients without asymptomatic inflammatory prostatitis, and whether asymptomatic inflammatory prostatitis affects long-term outcomes of transurethral resection of the prostate.
The present study involved 106 benign prostatic hyperplasia patients who underwent transurethral resection of the prostate. Clinical and pathological parameters were compared between those with benign prostatic hyperplasia associated with asymptomatic inflammatory prostatitis and those with benign prostatic hyperplasia alone.
A total of 55 patients (52%) were found to have benign prostatic hyperplasia and asymptomatic inflammatory prostatitis, whereas 51 patients (48%) had benign prostatic hyperplasia alone. The prostate volume of the benign prostatic hyperplasia/asymptomatic inflammatory prostatitis group was significantly larger than the benign prostatic hyperplasia alone group: 68.1 cm3 (interquartile range 45.7-86.3) versus 44.1 cm3 (interquartile range 30.9-72.1), P = 0.036. In terms of histopathological analysis, benign prostatic hyperplasia/asymptomatic inflammatory prostatitis patients were more likely to show mild (53%), focal (67%) and stromal (40%) prostatic inflammation in our study. Furthermore, statistically significant differences of International Prostate Symptom Score were found 3 years after transurethral resection of the prostate, with benign prostatic hyperplasia/asymptomatic inflammatory prostatitis patients reporting higher (worse) scores than benign prostatic hyperplasia alone patients (P = 0.025).
Chronic prostatic inflammatory process might progressively conduce to benign prostatic hyperplasia development, which can also result in prostate enlargement and worsen long-term postoperative International Prostate Symptom Scores. Multicenter studies with larger cohorts and longer follow-up periods are required to confirm these findings.
探讨无症状性炎症性前列腺炎是否与良性前列腺增生患者（不伴有无症状性炎症性前列腺炎）的前列腺增大有关，以及无症状性炎症性前列腺炎是否影响经尿道前列腺切除术的长期疗效。
本研究纳入了106例行经尿道前列腺切除术的良性前列腺增生患者。比较了伴有无症状性炎症性前列腺炎的良性前列腺增生患者与单纯良性前列腺增生患者的临床和病理参数。
共发现55例患者（52%）患有良性前列腺增生合并无症状性炎症性前列腺炎，而51例患者（48%）仅患有良性前列腺增生。良性前列腺增生/无症状性炎症性前列腺炎组的前列腺体积显著大于单纯良性前列腺增生组：68.1 cm³（四分位数间距45.7 - 86.3）对44.1 cm³（四分位数间距30.9 - 72.1），P = 0.036。在组织病理学分析方面，在我们的研究中，良性前列腺增生/无症状性炎症性前列腺炎患者更易出现轻度（53%）、局灶性（67%）和基质性（40%）前列腺炎症。此外，经尿道前列腺切除术后3年，国际前列腺症状评分存在统计学显著差异，良性前列腺增生/无症状性炎症性前列腺炎患者的评分高于单纯良性前列腺增生患者（评分更差）（P = 0.025）。
慢性前列腺炎症过程可能逐渐促进良性前列腺增生的发展，这也可导致前列腺增大并使术后长期国际前列腺症状评分恶化。需要进行更大样本量、更长随访期的多中心研究来证实这些发现。
