Gönczy Pierre
Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology (EPFL), School of Life Sciences, Lausanne, Switzerland.
Nat Rev Mol Cell Biol. 2008 May;9(5):355-66. doi: 10.1038/nrm2388.
Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals.
不对称细胞分裂是多细胞生物产生多样性的基础。由于在黑腹果蝇和秀丽隐杆线虫中开展的研究，如今人们对调控不对称细胞分裂的机制有了越来越深入的了解。从这两种模式生物中汲取的经验教训也适用于其他后生动物中进行不对称分裂的细胞，比如哺乳动物中的自我更新干细胞。
